Withaferin A

Withaferin A is the primary bioactive compound in ashwagandha (Withania somnifera) responsible for many of its powerful adaptogenic and anti-inflammatory benefits. Research shows it works through multiple mechanisms, including inhibiting inflammatory pathways like NF-κB, modulating stress hormones, and activating cellular stress response systems that enhance resilience. Clinical studies using ashwagandha extracts containing withaferin A demonstrate significant reductions in cortisol levels and stress symptoms, with one randomized controlled trial showing a 44% decrease in perceived stress scores and 28% reduction in cortisol levels after 60 days. Beyond stress management, withaferin A shows promising anticancer properties in laboratory studies by selectively targeting cancer cells through multiple pathways including inhibition of heat shock proteins, disruption of cancer cell division, and promotion of cancer cell death. Most supplements provide 300-600 mg of standardized ashwagandha extract containing approximately 5-30 mg of withaferin A daily. While generally well-tolerated, it may cause digestive discomfort in some people and should be avoided during pregnancy and by those with autoimmune conditions or thyroid disorders due to its potential immune-stimulating and thyroid-enhancing effects.