Nucleotides are essential building blocks of DNA and RNA that become conditionally essential nutrients during periods of rapid growth, immune challenges, and aging. Research shows they support immune function by enhancing antibody production and natural killer cell activity, while also promoting gut health by strengthening intestinal barrier integrity and supporting beneficial gut bacteria. Clinical studies demonstrate they can reduce the incidence of diarrhea, improve immune response to vaccines, and support recovery from illness or intense exercise. Most adults take 50-500 mg daily for general health, with higher doses (300-600 mg) sometimes used during recovery periods. While naturally present in foods like organ meats, seafood, and brewer’s yeast, supplemental forms are typically derived from yeast cells. Look for products that provide a balanced mix of different nucleotides (adenosine, guanosine, cytidine, uridine, and thymidine) rather than a single type for comprehensive benefits.
Alternative Names: Dietary Nucleotides, Nucleic Acid Derivatives, Nucleosides
Categories: Immune Modulators, Gut Health Supplements, Cellular Energy Enhancers
Primary Longevity Benefits
- Immune system enhancement
- Gut barrier integrity support
- Cellular regeneration and repair
- Microbiome modulation
Secondary Benefits
- Enhanced recovery from stress and illness
- Improved nutrient absorption
- Support for rapidly dividing cells
- Potential anti-inflammatory effects
- Enhanced athletic performance and recovery
Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications.