Palmitoylethanolamide (PEA) is an endogenous fatty acid amide that acts as a natural pain reliever and anti-inflammatory compound. It works primarily by activating PPAR-α receptors and modulating mast cell activity, with multiple clinical studies supporting its effectiveness for chronic pain conditions, particularly neuropathic pain. Unlike many pain medications, PEA has an excellent safety profile with minimal side effects and no risk of dependence. Micronized and ultramicronized forms offer better absorption than standard PEA. Typical dosages range from 300-1200mg daily, with many protocols using a higher loading dose followed by lower maintenance doses. PEA can be used alongside conventional treatments and may allow for reduced doses of other pain medications.
Alternative Names: PEA, N-palmitoylethanolamine, N-(2-hydroxyethyl)hexadecanamide, Palmidrol
Categories: Endogenous Lipid Mediator
Primary Longevity Benefits
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Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications.