Pangamic acid, sometimes called ‘vitamin B15,’ is a controversial supplement with an inconsistent chemical identity across different products and research studies. Most modern supplements labeled as pangamic acid contain primarily dimethylglycine (DMG). Despite claims dating back to Soviet-era research, pangamic acid is not recognized as a vitamin or essential nutrient by major regulatory agencies, including the FDA, which has maintained an import alert on pangamic acid products since the 1970s due to concerns about inconsistent composition. Proponents claim it enhances oxygen utilization, provides antioxidant support, and improves athletic performance, but scientific evidence for these benefits is limited and often contradictory. The most rigorous studies on DMG have failed to demonstrate significant performance-enhancing effects. While generally well-tolerated at typical doses (50-300 mg daily), the variable composition of products labeled as pangamic acid complicates safety assessments. For those seeking methyl donor benefits or performance enhancement, other supplements with better-established effects may be more appropriate.
Alternative Names: Vitamin B15, Calcium Pangamate, Dimethylglycine (DMG), Pangamate, Russian Vitamin B15, Gluconic Acid Dimethylaminoacetate
Categories: Pseudovitamin, Sometimes called B15
Primary Longevity Benefits
- Oxygen utilization
- Antioxidant support
- Cellular energy production
Secondary Benefits
- Athletic performance
- Cardiovascular health
- Liver function
- Immune support
- Cognitive function
Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications.