R Alpha Lipoic Acid

R-Alpha Lipoic Acid (R-ALA) is the natural, biologically active form of lipoic acid that provides superior antioxidant, mitochondrial, and neuroprotective benefits compared to synthetic racemic mixtures. Research shows it works as a universal antioxidant that functions in both water and fat-soluble environments, regenerates other antioxidants like vitamins C and E, and serves as a crucial cofactor for mitochondrial energy production. Clinical studies demonstrate significant benefits for diabetic neuropathy, with research showing it can reduce pain, numbness, and burning sensations by improving nerve function and blood flow. Beyond neuropathy, R-ALA shows promising effects for blood sugar regulation, with studies indicating it can enhance insulin sensitivity by up to 25-30% through activation of the insulin signaling pathway. It also provides liver protection, chelates heavy metals, and may support weight management through improved metabolic function. Most supplements provide 100-300 mg of R-ALA daily (equivalent to 200-600 mg of racemic ALA), with stabilized forms like sodium R-lipoate offering better absorption and bioavailability. For optimal benefits, take on an empty stomach 30 minutes before meals, as food can reduce absorption by 30-50%.